β Caryophyllene in S. aromaticum extract– Blocks CB2, Cannabinoid receptors
Uridine / methyl folate / Vitamin B6 / B12 – Nerve cell repair, Recovery of motor and sensor functions
Combination of above ingredients targeting various pain pathway will be effective in management of acute and chronic musculoskeletal pains.
The Evidence
Clinical evidence of Commiphora myrrha in treatment of chronic low back pain
An open label pilot study that demonstrated the efficacy of C. myrrha extract capsules in 204 Indian patients suffering from chronic low back pain. A significant pain reduction was observed from the 7 th day of treatment.
Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the Osteoarthritis
A randomized, placebo-controlled, double-blind trial with 201 patients of Osteoarthritis(OA) treated with Curcumin with that of Curcumin + Boswellia extract and placebo.
Efficacy of β- caryophyllene in delayed onset muscle soreness (DOMS) treatment
Efficacy of Syzygium aromaticum extract (standardized with β- caryophyllene) was confirmed with a randomized, double-blinded, crossover-designed, placebo-controlled study, conducted on 20 participants suffering from delayed onset muscle soreness (DOMS).
Role of Uridine and B Vitamins in treatment of Neuropathic pain
Uridine monophosphate (UMP)+Folic acid + Vitamin B12 supplementation in 212 patients of Neuropathic pain & Peripheral neuropathy; statistically significant reductions was observed not only in the total Pain detect questionnaire (PDQ) score